A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors

A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors

IntroductionNatural Killer (NK) cells play a key role in both innate and adaptive immune responses against viruses and tumor cells. Their function relies on the dynamic balance between activating and inhibitory signals, which are mediated by receptors that bind ligands expressed on target cells. Whi...

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Bibliographic Details
Main Authors: Paolo Romania, Loredana Cifaldi, Paula Gragera, Valerio D’Alicandro, Matteo Caforio, Valentina Folgiero, Valeria Lucarini, Ombretta Melaiu, Roberto Bei, Franco Locatelli, Doriana Fruci
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
NK cell
activating receptors
ligands
genome-wide screening
cancer immunotherapy
PLAC1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1537876/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1537876/full

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