Synthetic Analogs of the Alkaloid Cassiarin A with Enhanced Antimalarial Activity

Synthetic Analogs of the Alkaloid Cassiarin A with Enhanced Antimalarial Activity

<b>Background:</b> Among the alkaloids from <i>Cassia siamea</i>, cassiarin A has outstanding antiprotozoal activity, but structure–activity relationships for this chemotype were only poorly understood until now. <b>Methods:</b> We worked out efficient approaches...

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Bibliographic Details
Main Authors: Thomas Klaßmüller, Timo Reiß, Florian Lengauer, Che Julius Ngwa, Karin Bartel, Gabriele Pradel, Franz Bracher
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
cassiarin A
alkaloid
synthesis
antimalarial activity
structure–activity relationships
<i>Plasmodium falciparum</i>
Online Access:https://www.mdpi.com/1424-8247/18/7/1018
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https://www.mdpi.com/1424-8247/18/7/1018

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