Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition.

Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition.

The human fungal pathogen, Cryptococcus neoformans, dramatically alters its cell wall, both in size and composition, upon entering the host. This cell wall remodeling is essential for host immune avoidance by this pathogen. In a genetic screen for mutants with changes in their cell wall, we identifi...

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Bibliographic Details
Main Authors: Shannon K Esher, Kyla S Ost, Maria A Kohlbrenner, Kaila M Pianalto, Calla L Telzrow, Althea Campuzano, Connie B Nichols, Carol Munro, Floyd L Wormley, J Andrew Alspaugh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Pathogens
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.ppat.1007126/2/ppat.1007126.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210223%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210223T042927Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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