SPICE1 promotes osteosarcoma growth by enhancing the deubiquitination of FASN mediated by USP10

SPICE1 promotes osteosarcoma growth by enhancing the deubiquitination of FASN mediated by USP10

Abstract Background Osteosarcoma (OS) is recognized as a prevalent primary bone malignancy, particularly affecting adolescents during their growth spurts. Despite its clinical significance, the underlying biological characteristics and associated prognostic factors remain incompletely understood. Th...

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Bibliographic Details
Main Authors: Weilai Tong, Xinsheng Xie, Zhiguo Shu, Jiangbo Nie, Xianhe Yang, Feng Yang, Zhili Liu, Jiaming Liu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Translational Medicine
Subjects:
Osteosarcoma
SPICE1
FASN
USP10
Deubiquitination
Online Access:https://doi.org/10.1186/s12967-025-06248-1
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https://doi.org/10.1186/s12967-025-06248-1

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