Tumor microenvironment responsive Mn-based nanoplatform activate cGAS-STING pathway combined with metabolic interference for enhanced anti-tumor therapy

Tumor microenvironment responsive Mn-based nanoplatform activate cGAS-STING pathway combined with metabolic interference for enhanced anti-tumor therapy

Abstract Despite the encouraging developments in tumor immunotherapy, the complex tumor microenvironment (TME) and abnormal energy metabolism persist as key factors facilitating immune escape. Recent research has emphasized the significant potential of the Manganese ions (Mn2+) as a “immune ion reac...

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Bibliographic Details
Main Authors: E. Wen, Yu Tian, Yu Chen, Zhigang Wang, Yi Feng, Zhen Liao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Enhanced immunotherapy
Metabolic inhibition
Tumor microenvironment
STING pathway
Chemodynamic therapy
Online Access:https://doi.org/10.1186/s12951-025-03453-4
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https://doi.org/10.1186/s12951-025-03453-4

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