Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death

Abstract The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose withdrawal rapidly induces supra‐phys...

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Bibliographic Details
Main Authors: Nicholas A Graham, Martik Tahmasian, Bitika Kohli, Evangelia Komisopoulou, Maggie Zhu, Igor Vivanco, Michael A Teitell, Hong Wu, Antoni Ribas, Roger S Lo, Ingo K Mellinghoff, Paul S Mischel, Thomas G Graeber
Format: Article
Language:English
Published: Springer Nature 2012-06-01
Series:Molecular Systems Biology
Subjects:
cancer
metabolism
phosphatase
proteomics
reactive oxygen species
Online Access:https://doi.org/10.1038/msb.2012.20
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https://doi.org/10.1038/msb.2012.20

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