GPR56 function as a key repressor in hepatocyte pyroptosis and the pathogenesis of liver fibrosis

GPR56 function as a key repressor in hepatocyte pyroptosis and the pathogenesis of liver fibrosis

Abstract Background Given the rising prevalence of liver fibrosis, there is an urgent need to improve the effective diagnostic methods and treatment of liver fibrosis. Although GPCRs are involved in various physiological and pathological processes, however, the hepatic functions of GPR56 have rarely...

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Bibliographic Details
Main Authors: Zhemin Shi, Qi Liu, Mengxia Zhang, Xiaoxiao Du, Yifan He, Lina Zheng, Wei Hong, Tao Han, Kun Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Liver fibrosis
GPCR
Hepatocytes
Pyroptosis
Hepatic stellate cells
NF-κB
Online Access:https://doi.org/10.1186/s12967-025-06619-8
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https://doi.org/10.1186/s12967-025-06619-8

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