Up-regulation of blood-circulating TIM-4-expressing monocytes and potential diagnostic biomarker sTIM-4 in primary liver cancer

Up-regulation of blood-circulating TIM-4-expressing monocytes and potential diagnostic biomarker sTIM-4 in primary liver cancer

Abstract Primary hepatocellular carcinoma (PHC) remains a globally prevalent malignancy, where early diagnosis is critical. Monocytes have been implicated in tumor progression. This study investigated the expression of T cell immunoglobulin and mucin domain-containing protein 4 (TIM-4/TIMD4) in PHC...

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Bibliographic Details
Main Authors: Yifeng Yang, Yan Wei, Yilian Zhao, Chao Ye, Dan Zeng, Xiaoxing Zhou, Mengru Xie, Xingcai Chen, Jilin Qing, Zhizhong Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Primary liver cancer
TIM-4
sTIM-4
Blood-circulating monocyte subsets
Online Access:https://doi.org/10.1038/s41598-025-14361-w
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https://doi.org/10.1038/s41598-025-14361-w

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