New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer’s disease

New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer’s disease

Abstract Background The mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 (HSD10) is implicated in neurodegenerative disorders, particularly Alzheimer’s disease (AD), through its interplay with the amyloid-β peptide (Aβ). However, its independent pathological role in AD remains unclear....

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Bibliographic Details
Main Authors: Aneta Houfková, Monika Schmidt, Ondřej Benek, Ivo Fabrik, Rudolf Andrýs, Lucie Zemanová, Ondřej Soukup, Kamil Musílek
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
17β-hydroxysteroid dehydrogenase type 10
Amyloid-β peptide
Alzheimer’s disease
Amyloid precursor protein
Mitochondria
Online Access:https://doi.org/10.1186/s13195-025-01821-8
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https://doi.org/10.1186/s13195-025-01821-8

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