A basigin antibody modulates MCTs to impact tumor metabolism and immunity

A basigin antibody modulates MCTs to impact tumor metabolism and immunity

Abstract Lactate metabolism and signaling intricately intertwine in the context of cancer and immunity. Basigin, working alongside monocarboxylate transporters MCT1 and MCT4, orchestrates the movement of lactate across cell membranes. Despite their potential in treating formidable tumors, the mechan...

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Main Authors: Heng Zhang, Xuemei Yang, Yue Xue, Yi Huang, Yingxi Mo, Yurun Huang, Hong Zhang, Xiaofei Zhang, Weixin Zhao, Bin Jia, Ningning Li, Ning Gao, Yue Yang, Dongxi Xiang, Shan Wang, Yi Qin Gao, Jun Liao
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-025-00777-1
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https://doi.org/10.1038/s41421-025-00777-1

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