NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance
Abstract Alternative polyadenylation (APA) is critical for shaping transcriptome diversity and modulating cancer therapeutic resistance. While lactate is a well-established metabolic signal in cancer progression, its role in APA regulation remains unclear. Here, we demonstrate that l-lactate-induced...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-05-01
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| Series: | Cell Discovery |
| Online Access: | https://doi.org/10.1038/s41421-025-00804-1 |
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