Theoretical and experimental analysis links isoform‐ specific ERK signalling to cell fate decisions

Theoretical and experimental analysis links isoform‐ specific ERK signalling to cell fate decisions

Abstract Cell fate decisions are regulated by the coordinated activation of signalling pathways such as the extracellular signal‐regulated kinase (ERK) cascade, but contributions of individual kinase isoforms are mostly unknown. By combining quantitative data from erythropoietin‐induced pathway acti...

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Bibliographic Details
Main Authors: Marcel Schilling, Thomas Maiwald, Stefan Hengl, Dominic Winter, Clemens Kreutz, Walter Kolch, Wolf D Lehmann, Jens Timmer, Ursula Klingmüller
Format: Article
Language:English
Published: Springer Nature 2009-12-01
Series:Molecular Systems Biology
Subjects:
cytokine receptor
ERK
information processing
proliferation
sensitivity analysis
Online Access:https://doi.org/10.1038/msb.2009.91
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https://doi.org/10.1038/msb.2009.91

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