Effect of CFTR modulators on glucose homeostasis in children and young adults with cystic fibrosis-related diabetes: a systematic review

Effect of CFTR modulators on glucose homeostasis in children and young adults with cystic fibrosis-related diabetes: a systematic review

IntroductionCystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CFTR gene, leading to impaired chloride transport, thickened mucus, and multiorgan dysfunction. Among its complications, cystic fibrosis-related diabetes (CFRD) is a major concern, characterized by progres...

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Bibliographic Details
Main Authors: Paola Giordano, Giuseppina Leonetti, Vanja Granberg, Rosa Maria Pia Casolino, Giuseppe Lassandro, Maurizio Delvecchio, Giovanna Linguiti
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Endocrinology
Subjects:
cystic fibrosis
CFTR modulators
CFRD
glucose metabolism
lumacaftor/ivacaftor
elexacaftor-ivacaftor-tezacaftor
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1623654/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1623654/full

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