Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis
Background. Methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) gene polymorphisms are related to a growing risk of Alzheimer’s disease; however, whether this association applies to mild cognitive impairment (MCI) remains unclear. Objective. We conducted this meta-analysis to evaluate the...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2021/2962792 |
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| author | Jiahui Sun Xuefan Jiang Ming Zhao Lina Ma Hui Pei Nanyang Liu Hao Li |
| author_facet | Jiahui Sun Xuefan Jiang Ming Zhao Lina Ma Hui Pei Nanyang Liu Hao Li |
| author_sort | Jiahui Sun |
| collection | DOAJ |
| description | Background. Methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) gene polymorphisms are related to a growing risk of Alzheimer’s disease; however, whether this association applies to mild cognitive impairment (MCI) remains unclear. Objective. We conducted this meta-analysis to evaluate the contribution of MTHFR C677T (rs1801133) gene variants to the risk of MCI. Methods. PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases were searched from their inception to March 21, 2021, with language restricted to English or Chinese. We used fixed or random effects to examine the association between MTHFR C677T (rs1801133) gene variants and MCI susceptibility. Forest plots of pooled odds ratios (ORs) and 95% confidence intervals (CIs) were generated. Results. Eight articles with 2,175 participants were included in the present meta-analysis. There was no significant association between MTHFR C677T (rs1801133) gene variants and MCI susceptibility under the allelic (OR, 1.318; 95% CI, 0.964–1.801; p=0.084), dominant (OR, 1.296; 95% CI, 0.925–1.817; p=0.132), recessive (OR, 1.397; 95% CI, 0.845–2.312; p=0.193), heterozygous (OR, 1.031; 95% CI, 0.855–1.243; p=0.749), or homozygous (OR, 1.506; 95% CI, 0.850–2.667; p=0.160) models. Conclusion. The results suggest that MTHFR C677T (rs1801133) gene polymorphisms are not associated with MCI susceptibility. However, large-scale studies covering various factors are required. |
| format | Article |
| id | doaj-art-ee36f5dd38e947e59279f3d4b5e05b3c |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-ee36f5dd38e947e59279f3d4b5e05b3c2025-02-03T01:26:59ZengWileyBehavioural Neurology0953-41801875-85842021-01-01202110.1155/2021/29627922962792Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-AnalysisJiahui Sun0Xuefan Jiang1Ming Zhao2Lina Ma3Hui Pei4Nanyang Liu5Hao Li6Graduate School, Beijing University of Chinese Medicine, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Geratology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Geratology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Geratology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Geratology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaBackground. Methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) gene polymorphisms are related to a growing risk of Alzheimer’s disease; however, whether this association applies to mild cognitive impairment (MCI) remains unclear. Objective. We conducted this meta-analysis to evaluate the contribution of MTHFR C677T (rs1801133) gene variants to the risk of MCI. Methods. PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases were searched from their inception to March 21, 2021, with language restricted to English or Chinese. We used fixed or random effects to examine the association between MTHFR C677T (rs1801133) gene variants and MCI susceptibility. Forest plots of pooled odds ratios (ORs) and 95% confidence intervals (CIs) were generated. Results. Eight articles with 2,175 participants were included in the present meta-analysis. There was no significant association between MTHFR C677T (rs1801133) gene variants and MCI susceptibility under the allelic (OR, 1.318; 95% CI, 0.964–1.801; p=0.084), dominant (OR, 1.296; 95% CI, 0.925–1.817; p=0.132), recessive (OR, 1.397; 95% CI, 0.845–2.312; p=0.193), heterozygous (OR, 1.031; 95% CI, 0.855–1.243; p=0.749), or homozygous (OR, 1.506; 95% CI, 0.850–2.667; p=0.160) models. Conclusion. The results suggest that MTHFR C677T (rs1801133) gene polymorphisms are not associated with MCI susceptibility. However, large-scale studies covering various factors are required.http://dx.doi.org/10.1155/2021/2962792 |
| spellingShingle | Jiahui Sun Xuefan Jiang Ming Zhao Lina Ma Hui Pei Nanyang Liu Hao Li Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis Behavioural Neurology |
| title | Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis |
| title_full | Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis |
| title_fullStr | Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis |
| title_short | Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis |
| title_sort | association of methylenetetrahydrofolate reductase c677t gene polymorphisms with mild cognitive impairment susceptibility a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2021/2962792 |
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