Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs

Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs

Abstract Many cancer risk variants are located within enhancer regions and lack sufficient molecular interpretation. Here, we constructed the first comprehensive atlas of enhancer RNA (eRNA)‐mediated genetic effects from 28 033 RNA sequencing samples across 11 606 individuals, identifying 21 073 eRN...

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Main Authors: Wenyan Chen, Zeyang Wang, Yinuo Wang, Jianxiang Lin, Shuxin Chen, Hui Chen, Xuelian Ma, Xudong Zou, Xing Li, Yangmei Qin, Kewei Xiong, Xixian Ma, Qi Liao, Yunbo Qiao, Lei Li
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
enhancer RNA
genome‐wide association study
noncoding variants
pan‐cancer
transcriptome‐wide association study
Online Access:https://doi.org/10.1002/advs.202411974
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https://doi.org/10.1002/advs.202411974

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