JAK2 inactivating mutations promotes endometrial cancer progression by targeting HIF-1α

JAK2 inactivating mutations promotes endometrial cancer progression by targeting HIF-1α

Abstract Objective Endometrial cancer (EC) is the ninth most common malignancy among women. While mutations in JAK2 are frequently observed in EC, the specific biological functions of JAK2 in endometrial cancer are poorly understood. Methods The genetic alterations of JAK2 in different cancer types...

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Bibliographic Details
Main Authors: Zheng Chen, Xuan Zheng, Weijian Zeng, Juan Wang, Qin Lin
Format: Article
Language:English
Published: Springer 2024-12-01
Series:Discover Oncology
Subjects:
Endometrial cancer
JAK2
HIF-1α
Inactivating mutations
Online Access:https://doi.org/10.1007/s12672-024-01722-6
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https://doi.org/10.1007/s12672-024-01722-6

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