Rescuing vascular dysfunction in dorsal pancreatic arteries prevents tacrolimus-induced glucose metabolism disorder in mice

Rescuing vascular dysfunction in dorsal pancreatic arteries prevents tacrolimus-induced glucose metabolism disorder in mice

Abstract Long-term adverse effects of the immunosuppressant tacrolimus (Tac), such as nephrotoxicity, hepatotoxicity and diabetes, have been widely reported. Up to 33.6% of solid organ transplantation patients receiving Tac treatment develop hyperglycemia; however, the underlying mechanisms remain p...

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Main Authors: Lingyan Fei, Honghong Wang, Dongliang Zhao, Xiaohua Wang, Jizhen Ren, Lanyun Liu, Chun Tang, Yan Lei, Qingqing Wang, Yuanpeng Nie, Yang Liu, Na Li, Ming Zhong, Nan Xu, Jin Wei, Pontus B. Persson, Andraes Patzak, Pratik H. Khedkar, Zhihua Zheng, Shan Jiang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
Tacrolimus
Dorsal pancreatic arteries
Vascular dysfunction
Hypoxia
Hyperglycemia
Online Access:https://doi.org/10.1186/s10020-025-01282-7
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https://doi.org/10.1186/s10020-025-01282-7

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