Patient-derived ovarian cancer models demonstrate the influence of tumor-associated macrophages on therapeutic response

Patient-derived ovarian cancer models demonstrate the influence of tumor-associated macrophages on therapeutic response

While most ovarian cancer (OC) patients respond to front-line platinum/taxane chemotherapy and surgical debulking, the majority will develop platinum-resistance and recur. Our study investigated how tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) affect chemotherapy outco...

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Bibliographic Details
Main Authors: Parisa Nikeghbal, Danielle Burke, Dalet Armijo, Samuel Aldarondo-Quiñones, Diane S. Lidke, Mara P. Steinkamp
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Chemotherapy
humanized PDX
immunotherapy
organoids
ovarian cancer
patient-derived models
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2537710
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https://www.tandfonline.com/doi/10.1080/2162402X.2025.2537710

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