The Clinical Utility of Precision-Guided Dosing for Adalimumab Therapy Optimization in Inflammatory Bowel Disease: A Clinical Experience Program

The Clinical Utility of Precision-Guided Dosing for Adalimumab Therapy Optimization in Inflammatory Bowel Disease: A Clinical Experience Program

<b>Background/Objectives</b>: This study aimed to establish the clinical utility of a therapeutic drug monitoring (TDM)-supported, model-informed precision dosing (MIPD) approach (precision-guided dosing [PGD]) by assessing the impact of pharmacokinetic (clearance [CL]) and clinical labo...

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Main Authors: Stephen B. Hanauer, Esther A. Torres, Patricia Aragon-Han, Jonathon C. Chapman, Arun C. Swaminath, Ronen Arai, Mandalina Butnariu, Thomas C. Lee, Shervin Rabizadeh, Morgan Check, Terrence A. Barrett, Jana G. Hashash, Thomas Meister, Eugene F. Yen, Jami Kinnucan, Daniel J. Stein, David Ziring, Rimma Shaposhnikov, Preetika Sinh, Taha M. Qazi, Andres J. Yarur, Farah Monzur, Thierry Dervieux, Bincy P. Abraham
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceutics
Subjects:
precision-guided dosing
precision medicine
dose optimization
real-world data
clearance
adalimumab
Online Access:https://www.mdpi.com/1999-4923/17/4/428
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