A systematic literature review of MTAP deletions in solid and hematologic Cancers

A systematic literature review of MTAP deletions in solid and hematologic Cancers

Background: Methylthioadenosine phosphorylase (MTAP) deficiency is observed across multiple cancers and represents an emerging biomarker with therapeutic potential via synthetic lethality with PRMT5 inhibition. This systematic literature review summarizes the prevalence of MTAP deletions or loss of...

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Bibliographic Details
Main Authors: Mary C. Clouser, Mina Suh, Naimisha Movva, Janet S. Hildebrand, Susan T. Pastula, Martina Schoehl, Antreas Hindoyan, Akhila Balasubramanian, Jon P. Fryzek, Soo-Ryum Yang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cancer Treatment and Research Communications
Subjects:
Cancer
CDKN2A
Co-mutations
Homozygous deletions
MTAP
Survival
Online Access:http://www.sciencedirect.com/science/article/pii/S2468294225001029
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