Role of Quercetin in Diabetic Cardiomyopathy
Diabetic cardiomyopathy is a significant and severe complication of diabetes that affects a large portion of the global population, with its prevalence continuing to rise. Secondary metabolites, including quercetin, have shown promising effects in mitigating the progression of diabetic cardiomyopath...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2223-7747/14/1/25 |
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| author | Nor Hidayah Mustafa Hawa Nordin Siti Yusof Kamisah |
| author_facet | Nor Hidayah Mustafa Hawa Nordin Siti Yusof Kamisah |
| author_sort | Nor Hidayah Mustafa |
| collection | DOAJ |
| description | Diabetic cardiomyopathy is a significant and severe complication of diabetes that affects a large portion of the global population, with its prevalence continuing to rise. Secondary metabolites, including quercetin, have shown promising effects in mitigating the progression of diabetic cardiomyopathy by targeting multiple pathological mechanisms, including impaired insulin signaling, glucotoxicity, lipotoxicity, oxidative stress, inflammation, fibrosis, apoptosis, autophagy, mitochondrial dysfunction, cardiac stiffness, and disrupted calcium handling. Addressing these mechanisms is crucial to prevent left ventricular diastolic and systolic dysfunction in advanced stages of diabetic heart disease. Scientific evidence has highlighted the cardioprotective properties of quercetin at both the myocardial and cellular/molecular levels in diabetic models. Therefore, this review aims to present a comprehensive overview of the proposed mechanisms underlying quercetin’s beneficial effects, providing valuable insights that could inform future drug discovery efforts specific to diabetic cardiomyopathy. |
| format | Article |
| id | doaj-art-edd1be1ca91742f38ea4a4cba493f512 |
| institution | Kabale University |
| issn | 2223-7747 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj-art-edd1be1ca91742f38ea4a4cba493f5122025-01-10T13:19:31ZengMDPI AGPlants2223-77472024-12-011412510.3390/plants14010025Role of Quercetin in Diabetic CardiomyopathyNor Hidayah Mustafa0Hawa Nordin Siti1Yusof Kamisah2Centre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaDepartment of Basic Medical Sciences, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu 20400, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaDiabetic cardiomyopathy is a significant and severe complication of diabetes that affects a large portion of the global population, with its prevalence continuing to rise. Secondary metabolites, including quercetin, have shown promising effects in mitigating the progression of diabetic cardiomyopathy by targeting multiple pathological mechanisms, including impaired insulin signaling, glucotoxicity, lipotoxicity, oxidative stress, inflammation, fibrosis, apoptosis, autophagy, mitochondrial dysfunction, cardiac stiffness, and disrupted calcium handling. Addressing these mechanisms is crucial to prevent left ventricular diastolic and systolic dysfunction in advanced stages of diabetic heart disease. Scientific evidence has highlighted the cardioprotective properties of quercetin at both the myocardial and cellular/molecular levels in diabetic models. Therefore, this review aims to present a comprehensive overview of the proposed mechanisms underlying quercetin’s beneficial effects, providing valuable insights that could inform future drug discovery efforts specific to diabetic cardiomyopathy.https://www.mdpi.com/2223-7747/14/1/25quercetindiabetesheart diseaseoxidative stressinflammationcalcium regulation |
| spellingShingle | Nor Hidayah Mustafa Hawa Nordin Siti Yusof Kamisah Role of Quercetin in Diabetic Cardiomyopathy Plants quercetin diabetes heart disease oxidative stress inflammation calcium regulation |
| title | Role of Quercetin in Diabetic Cardiomyopathy |
| title_full | Role of Quercetin in Diabetic Cardiomyopathy |
| title_fullStr | Role of Quercetin in Diabetic Cardiomyopathy |
| title_full_unstemmed | Role of Quercetin in Diabetic Cardiomyopathy |
| title_short | Role of Quercetin in Diabetic Cardiomyopathy |
| title_sort | role of quercetin in diabetic cardiomyopathy |
| topic | quercetin diabetes heart disease oxidative stress inflammation calcium regulation |
| url | https://www.mdpi.com/2223-7747/14/1/25 |
| work_keys_str_mv | AT norhidayahmustafa roleofquercetinindiabeticcardiomyopathy AT hawanordinsiti roleofquercetinindiabeticcardiomyopathy AT yusofkamisah roleofquercetinindiabeticcardiomyopathy |