β-caryophyllene sensitizes hepatocellular carcinoma cells to chemotherapeutics and inhibits cell malignancy through targeting MAPK signaling pathway

β-caryophyllene sensitizes hepatocellular carcinoma cells to chemotherapeutics and inhibits cell malignancy through targeting MAPK signaling pathway

Backgroundβ-caryophyllene (BCP) is a naturally occurring bicyclic sesquiterpene extracted from various plants, and widely used as a medicinal agent for various diseases. During hepatocellular carcinoma (HCC) development, cancer cells generally exhibit increased cell proliferation due to mutations or...

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Bibliographic Details
Main Authors: Irum Basheer, Hai Wang, Guangyue Li, Shah Jehan, Ali Raza, Chentao Du, Najeeb Ullah, Dangdang Li, Guangchao Sui
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
hepatocellular carcinoma
β-caryophyllene
anti-cancer activity
combinatorial treatment
RNA-seq
placental growth factor (PGF)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1492670/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1492670/full

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