Mesoporous Polydopamine Nano-Bowls Demonstrate a High Entrapment Efficiency and pH-Responsive Release of Paclitaxel for Suppressing A549 Lung Cancer Cell Proliferation In Vitro

Mesoporous Polydopamine Nano-Bowls Demonstrate a High Entrapment Efficiency and pH-Responsive Release of Paclitaxel for Suppressing A549 Lung Cancer Cell Proliferation In Vitro

<b>Background:</b> The effectiveness of paclitaxel (PTX) in treating non-small-cell lung carcinoma (NSCLC) is restricted by its poor pharmacokinetic profile and side effects. This limitation stems from the lack of a suitable delivery vector to efficiently target cancer cells. Therefore,...

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Bibliographic Details
Main Authors: Lindokuhle M. Ngema, Shahinur Acter, Samson A. Adeyemi, Thashree Marimuthu, Mershen Govender, Wilfred Ngwa, Yahya E. Choonara
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
mesoporous nanoparticles
polydopamine
paclitaxel
non-small-cell lung carcinoma
anti-proliferation
Online Access:https://www.mdpi.com/1999-4923/16/12/1536
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