Large-scale transcriptome mining enables macrocyclic diversification and improved bioactivity of the stephanotic acid scaffold

Large-scale transcriptome mining enables macrocyclic diversification and improved bioactivity of the stephanotic acid scaffold

Abstract Nearly 10,000 plant species are represented by RNA-seq datasets in the NCBI sequence read archive, which are difficult to search in unassembled format due to database size. Here, we optimize RNA-seq assembly to transform most of this public RNA-seq data to a searchable database for biosynth...

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Main Authors: Xiaofeng Wang, Khadija Shafiq, Derrick A. Ousley, Desnor N. Chigumba, Dulciana Davis, Kali M. McDonough, Lisa S. Mydy, Jonathan Z. Sexton, Roland D. Kersten
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59428-4
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https://doi.org/10.1038/s41467-025-59428-4

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