Impact of phenytoin and valproic acid on cytotoxicity and inflammatory mediators in human mononuclear cells: with and without lipopolysaccharide stimulation

Impact of phenytoin and valproic acid on cytotoxicity and inflammatory mediators in human mononuclear cells: with and without lipopolysaccharide stimulation

Background Valproic acid (VPA) is known for its broad-spectrum antiepileptic effects and is recommended for generalized epilepsy, in contrast to phenytoin, which has a more limited spectrum. This study investigated the cytotoxic and inflammatory responses to phenytoin and VPA in peripheral blood mon...

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Bibliographic Details
Main Authors: Aminah Alesawy, Norah Alotaibi, Marwa Alalshaikh, Faisal E. Aljofi, Nada Aldossary, Nada Al-Zahrani, Omar Omar, Marwa Madi
Format: Article
Language:English
Published: PeerJ Inc. 2025-03-01
Series:PeerJ
Subjects:
Phenytoin
Valproic acid
Antiepileptic drugs
Mononuclear cells
Cytotoxicity
Inflammatory mediators
Online Access:https://peerj.com/articles/19102.pdf
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