Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing

Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing

BackgroundRenal fibrosis, characterized by the abnormal accumulation of extracellular matrix in renal tissue and progressive loss of kidney function, is posing a significant challenge in clinical treatment. While several therapeutic options exist, effective treatments remain limited. Inonotus obliqu...

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Bibliographic Details
Main Authors: Yueling Peng, Yaling Zhang, Rui Wang, Xinyu Wang, Xingwei Liu, Hui Liao, Rongshan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
renal fibrosis
single-cell RNA sequencing
traditional Chinese medicine
proximal tubular cells
macrophages
t cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1556739/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1556739/full

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