SUMOylation of SETD8 Promotes Tumor Growth by Methylating and Stabilizing MYC in Bladder Cancer

SUMOylation of SETD8 Promotes Tumor Growth by Methylating and Stabilizing MYC in Bladder Cancer

Abstract Aberrant transcriptional and epigenetic landscape plays crucial roles in the progression of bladder cancer (BC). However, effective therapeutic targets derived from these processes remain undeveloped. This study pinpoints SET‐domain‐containing protein 8 (SETD8) as a pivotal gene that promot...

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Main Authors: Xia Zhang, Zhenxuan Chen, Xiaobo He, Jingxuan Wang, Jianliang Zhong, Yezi Zou, Xianchong Zheng, Yujie Lin, Ruhua Zhang, Tiebang Kang, Liwen Zhou, Yuanzhong Wu
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
bladder cancer (BC)
methylation
MYC
SETD8
SUMOylation
tumor growth
Online Access:https://doi.org/10.1002/advs.202501734
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https://doi.org/10.1002/advs.202501734

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