The Cytoplasmic Tail of Ovine Herpesvirus 2 Glycoprotein B Affects Cell Surface Expression and Is Required for Membrane Fusion

The Cytoplasmic Tail of Ovine Herpesvirus 2 Glycoprotein B Affects Cell Surface Expression and Is Required for Membrane Fusion

Ovine herpesvirus 2 (OvHV-2) causes the fatal veterinary disease malignant catarrhal fever (MCF). Fusion is an essential step in the host cell entry of enveloped viruses and is an important target for vaccine development. OvHV-2 cannot be propagated in vitro, so a robust virus-free cell–cell membran...

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Bibliographic Details
Main Authors: Colleen M. Lynch, Maria K. Herndon, McKenna A. Hull, Daniela D. Moré, Katherine N. Baker, Cristina W. Cunha, Anthony V. Nicola
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Viruses
Subjects:
ovine herpesvirus 2
glycoprotein B
surface expression
fusion
Online Access:https://www.mdpi.com/1999-4915/17/7/994
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