Alpha-ketoglutarate promotes anxiety, activates autophagy, and suppresses antioxidant enzymes in the cerebral cortex of female mice on cafeteria diet

Alpha-ketoglutarate promotes anxiety, activates autophagy, and suppresses antioxidant enzymes in the cerebral cortex of female mice on cafeteria diet

Alpha-ketoglutarate (AKG), an intermediate of the tricarboxylic acid cycle, has been found to mitigate oxidative stress and inflammation. In turn, a cafeteria diet (CD), an obesogenic diet, is often associated with oxidative stress and inflammation. This study aimed to determine whether AKG can leve...

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Bibliographic Details
Main Authors: Oleh Demianchuk, Maria Bayliak, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoriia Hurza, Vitalii Derkachov, Vladyslav Berezovskyi, Volodymyr I. Lushchak
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Brain Research Bulletin
Subjects:
Alpha-ketoglutarate
Autophagy
Antioxidant response
Cafeteria diet
Behavior
Brain metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S036192302500067X
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http://www.sciencedirect.com/science/article/pii/S036192302500067X

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