Botulinum Toxin Type A Exerts Direct Trans-Synaptic Action at Bilateral Spinal Nociceptive Circuits

Botulinum Toxin Type A Exerts Direct Trans-Synaptic Action at Bilateral Spinal Nociceptive Circuits

Botulinum toxin type A (BoNT-A) induces a bilateral analgesic effect following unilateral injection in rodent bilateral or mirror pain models. This occurs either by indirect plasticity-related actions, or by the toxin’s direct central action in bilateral spinal circuits. Herein, we aimed to resolve...

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Bibliographic Details
Main Authors: Dalia Nemanić, Petra Šoštarić, Patrik Meglić, Ivica Matak, Lidija Bach-Rojecky
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Toxins
Subjects:
botulinum toxin type A
trans-synaptic transport
carrageenan-induced bilateral inflammatory pain
neutralizing antitoxin
c-Fos immunohistochemistry
synaptosomal-associated protein 25
Online Access:https://www.mdpi.com/2072-6651/17/3/140
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