TRPC3/6 Channels Mediate Mechanical Pain Hypersensitivity via Enhancement of Nociceptor Excitability and of Spinal Synaptic Transmission

TRPC3/6 Channels Mediate Mechanical Pain Hypersensitivity via Enhancement of Nociceptor Excitability and of Spinal Synaptic Transmission

Abstract Patients with tissue inflammation or injury often experience aberrant mechanical pain hypersensitivity, one of leading symptoms in clinic. Despite this, the molecular mechanisms underlying mechanical distortion are poorly understood. Canonical transient receptor potential (TRPC) channels co...

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Main Authors: Zhi‐Chuan Sun, Wen‐Juan Han, Zhi‐Wei Dou, Na Lu, Xu Wang, Fu‐Dong Wang, Sui‐Bin Ma, Zhi‐Cheng Tian, Hang Xian, Wan‐Neng Liu, Ying‐Ying Liu, Wen‐Bin Wu, Wen‐Guang Chu, Huan Guo, Fei Wang, Hui Ding, Yuan‐Ying Liu, Hui‐Ren Tao, Marc Freichel, Lutz Birnbaumer, Zhen‐Zhen Li, Rou‐Gang Xie, Sheng‐Xi Wu, Ceng Luo
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
mechanical pain hypersensitivity
nociceptor
synaptic potentiation
TRPC3
TRPC6
Online Access:https://doi.org/10.1002/advs.202404342
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https://doi.org/10.1002/advs.202404342

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