The alteration of IL-17 signaling pathway in bipolar disorder: a preliminary study with transcriptomic perspective

The alteration of IL-17 signaling pathway in bipolar disorder: a preliminary study with transcriptomic perspective

ObjectiveBipolar Disorder (BD) is a complex psychiatric condition influenced by genetic and environmental factors. This study aims to explore global mRNA expression in Peripheral blood white cells (PBMC) of BD patients.MethodsWe analyzed whole-genome gene expression profiles from PBMC of 12 BD state...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiaobo Wang, Su Yu, Zhen Gao, Fangming Xu, Yumei Wang, Tianle Zhang, Tingting Xie, Xihua Jia
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Psychiatry
Subjects:	bipolar disorder DEGs (differentially expressed genes) IL-17 pathway immunoinflammatory response immune infiltration analysis
Online Access:	https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1539038/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

IL-17A, IL-17F and IL-23 in patients with rheumatoid arthritis
by: Natalia A. Lapkina, et al.
Published: (2024-09-01)

Contribution of IL-17C-mediated macrophage polarization to Type 17 inflammation in neutrophilic asthma
by: Yuhuan Wen, et al.
Published: (2024-11-01)

Association of polymorphism of IL‐17A, IL‐17F, and IL‐6 with Toxoplasma gondii infection susceptibility in HIV/AIDS patients in Shiraz, southern Iran
by: Maryam Nejabat, et al.
Published: (2024-01-01)

Assessment of The Impact of Apremilast on Levels of IL-17, IL-23, and Lipids in Obese Psoriatic Patient
by: Haitham M. Saad, et al.
Published: (2024-12-01)

The level of IL-1?, IL-10 and IL-17A in Alzheimer's disease patients: Comparative study
by: Baghdad Science Journal
Published: (2014-12-01)

IL-17 in Protective Immunity to Vaginal Candidiasis
by: Baghdad Science Journal
Published: (2016-03-01)

Study on serum TL1A levels and their correlation with Th17 cells, IL-17 and IL-21 in children with Graves’ disease
by: Lijun Hao, et al.
Published: (2024-12-01)

Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells
by: Constanza Rodriguez, et al.
Published: (2023-12-01)

The role of interleukin 17 in the pathogenesis of rheumatoid arthritis. Are there any prospects for the use of IL-17 inhibitors?
by: E. L. Nasonov, et al.
Published: (2023-04-01)

IL‐17A Mediates Depressive‐Like Symptoms by Inducing Microglia Activation in Psoriasiform Dermatitis Mice
by: Yue Dou, et al.
Published: (2024-12-01)

Genetic Variants of the IL‐23/IL‐17 Axis and Its Association With Periodontal Disease: A Systematic Review
by: Ruth Rodríguez‐Montaño, et al.
Published: (2025-02-01)

The dual role of IL-17 in periodontitis regulating immunity and bone homeostasis
by: Zhongyuan Tang, et al.
Published: (2025-04-01)

Effect of Aerobic Training with Aqueous Allium sativum L on IL-17, IL-22 Expression and Insulin Resistance in Diabetic Rats
by: Elnaz Sadeghpour Firozabadi, et al.
Published: (2023-03-01)

Aspectos de la IL-17 en la inmunopatogénesis de la psoriasis: un nuevo blanco terapéutico
by: Luis Carlos Ramírez, et al.
Published: (2019-08-01)

The Role of IL-23 in the Development of Th17 Lymphocytes in Pulmonary Tuberculosis Patients
by: T. E. Kononova, et al.
Published: (2023-12-01)

Impact of IL-17A Inhibitors on Serum Uric Acid Levels in Psoriatic Patients with Hyperuricemia: A Prospective Observational Study
by: Wu C, et al.
Published: (2024-11-01)

The role of IL-17 family cytokines in cardiac fibrosis
by: Liqing Huang
Published: (2024-10-01)

Serum levels of interleukin-17, -18, -22, and -25 in patients with bullous pemphigoid before and after treatment
by: Xinyi Hong, et al.
Published: (2025-07-01)

Effect of Ag nanoparticles on expression of fnbA gene in S. aureus and evaluation of IL-10 and IL-17 levels among burn patients
by: Reyam Majeed Hassan, et al.
Published: (2024-06-01)

Investigation of the Relationship Between IL-17, IL-27, IL-2 Blood Levels in Spontaneous Abortion and Healthy Pregnant Women
by: Gurkan Ozbey, et al.
Published: (2025-02-01)

Case Report: Infliximab for hydroxychloroquine-induced AGEP with IL17A and IL36RN mutations: a case report and management considerations
by: Xiaoyun Jiang, et al.
Published: (2025-07-01)

The Impact of IL-17A Inhibition in Rheumatic and Musculoskeletal Diseases: Current Insights and Future Prospects
by: Sofia Ramiro, et al.
Published: (2025-04-01)

Xuetongsu attenuates synovial inflammation in rheumatoid arthritis by inhibiting the IL-23/IL-17/NF-κB inflammatory axis
by: Yuxin Chen, et al.
Published: (2025-08-01)

IL-23/IL-17 INHIBITORS IN IMMUNOINFLAMMATORY RHEUMATIC DISEASES: NEW HORIZONS
by: E. L. Nasonov, et al.
Published: (2019-09-01)

Tapak Liman (Elephantopus scaber L.) Leaves Ethanol Extract Improves the Production of IL-6 and IL-17 Cytokines in Mice with Bleomycin-induced Pulmonary Fibrosis
by: Sarah Nahdah Nabilah, et al.
Published: (2024-02-01)

IL-17A in gastric carcinogenesis: good or bad?
by: Weidong Li, et al.
Published: (2024-11-01)

FOSL1 promotes keratinocyte migration and wound repair by modulating the IL17 signaling pathway
by: Haoran Mao, et al.
Published: (2025-05-01)

Development and validation of a nomogram for predicting the risk of obstructive coronary artery disease in rheumatoid arthritis patients based on LDL-C, Th17 cells, and IL-17
by: Xiaoyang Wang, et al.
Published: (2024-12-01)

Exploration of biomarkers for predicting the prognosis of patients with diffuse large B-cell lymphoma by machine-learning analysis
by: Shifen Wang, et al.
Published: (2025-08-01)

Cytokine dynamics in vitiligo: the roles of interleukin-10 and interleukin-17
by: Hanan Mohammed Saied
Published: (2025-08-01)

Targeting nail psoriasis: IL-17A inhibitors demonstrate site-specific superiority over IL-23 inhibitor in a 24-week dermoscopy-guided real-world cohort
by: Xiamei Yan, et al.
Published: (2025-04-01)

The study of pharmacodynamics of a medicine based on humanized monoclonal antibodies against IL-17 in rabbit model of antigen-induced arthritis
by: A. A. Nedorubov, et al.
Published: (2018-02-01)

The Role of IL-6 and IL-17 in SARS CoV-2 Patients with Secondary Bacterial Pneumonia
by: May Raheem Ali, et al.
Published: (2023-02-01)

Allelic, Genotypic, and Haplotypic Analysis of Cytokine IL17A, IL17F, and Toll-like Receptor TLR4 Gene Polymorphisms in Metabolic-Dysfunction-Associated Steatotic Liver Disease: Insights from an Exploratory Study
by: Sorina-Cezara Coste, et al.
Published: (2024-10-01)

IL-17A in COVID-19 Cases: a meta-analysis
by: Sukayna Fadlallah, et al.
Published: (2021-11-01)

Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis
by: Ali Tadayon, et al.
Published: (2024-12-01)

Reduced IL-17A levels in neonates born to mothers with diabetes mellitus or infection during pregnancy
by: Tingting Li, et al.
Published: (2025-08-01)

Case Report: Spesolimab for pyoderma gangrenosum in an undifferentiated oligoarthritis patient receiving anti-IL-17 therapy
by: Weiwei Xin, et al.
Published: (2025-04-01)

Mechanistic Studies on the Role of IL-17/NLRP3 in Arsenic-Induced Activation of Hepatic Stellate Cells Through Hepatocyte Proptosis
by: Ting Hu, et al.
Published: (2025-04-01)

Expression of IL-17 on Breast Cancer Mice Treated by Combination of Phyllanthus Urinaria and Catharanthus roseus Extract
by: Aya Shofiyah, et al.
Published: (2022-06-01)