IRAP Drives Ribosomal Degradation to Refuel Energy for Platelet Activation during Septic Thrombosis

IRAP Drives Ribosomal Degradation to Refuel Energy for Platelet Activation during Septic Thrombosis

Abstract Platelets play crucial roles in multiple pathophysiological processes after energy‐dependent activation. It is puzzling how such a small cellular debris has abundant energy supply. In this study, it is shown that insulin‐regulated aminopeptidase (IRAP), a type II transmembrane protein, is a...

Full description

Saved in:
Bibliographic Details
Main Authors: Baichuan Xu, Xianpeng Ye, Kangfu Sun, Liang Chen, Zhaoyang Wen, Qigang Lan, Jun Chen, Mo Chen, Mingqiang Shen, Song Wang, Yang Xu, Xi Zhang, Jinghong Zhao, Junping Wang, Shilei Chen
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
platelet
IRAP (LNPEP)
ribophagy
ribosome
sepsis
thrombosis
Online Access:https://doi.org/10.1002/advs.202411914
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/advs.202411914

Similar Items