Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations

Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations

Background and objectiveRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the hyperproliferation and invasive behavior of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), which contributes to the degradation of articular cartilage and bone. Inhibition of RA-FLS pr...

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Bibliographic Details
Main Authors: Jiacheng Shen, Yuxuan Fang, Nan Xu, Hongyi Chen, Miao Zhu, Dan Li, Zewen Chu, Masataka Sunagawa, Yanqing Liu, Haibo Wang, Guoqing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
rheumatoid arthritis
triptolide
cytoskeleton
RhoA/Rho-associated kinase
network pharmacology
molecular dynamics simulations
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1545514/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1545514/full

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