PNMA1 mediates melphalam chemoresistance in retinoblastoma via promoting DNA repair
Abstract Retinoblastoma (RB) is the most common malignant eye tumor in children. Cytotoxic drugs like melphalam often cause significant side effects and acquired resistance in RB treatment. Here, the impact of Paraneoplastic Ma1 (PNMA1) on RB progression and chemotherapy resistance was investigated....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-12206-0 |
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