VMP1 attenuates ferroptosis and mitochondrial dysfunction in nucleus pulposus cells through the PINK1/Parkin-mediated mitophagy pathway

VMP1 attenuates ferroptosis and mitochondrial dysfunction in nucleus pulposus cells through the PINK1/Parkin-mediated mitophagy pathway

Abstract Background Intervertebral disc degeneration (IVDD) is a multifactorial disorder and a leading contributor to chronic low back pain (LBP), highlighting the need for novel therapeutic strategies. Recent studies indicate that ferroptosis, driven by oxidative stress, plays a key role in the los...

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Bibliographic Details
Main Authors: Yang Zhang, Yucheng Gao, Shuanggong Liu, Guowei Yang, Yijun Rong, Dongjin Wu, Zengxin Gao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
IVDD
VMP1
Ferroptosis
Mitochondrial dysfunction
Mitophagy
Online Access:https://doi.org/10.1186/s13018-025-06033-2
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https://doi.org/10.1186/s13018-025-06033-2

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