Evaluating image-derived input functions for cerebral [18F]MC225 PET studies

Evaluating image-derived input functions for cerebral [18F]MC225 PET studies

Kinetic modelling of brain PET data is crucial for estimating quantitative biological parameters, traditionally requiring arterial sampling. This study evaluated whether arterial samples could be omitted to estimate the image-derived input function (IDIF) using a long axial field-of-view PET scanner...

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Bibliographic Details
Main Authors: Giordana Salvi de Souza, Pascalle Mossel, Joost F. Somsen, Laura Providência, Anna L. Bartels, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Cristiane R. G. Furini, Adriaan A. Lammertsma, Charalampos Tsoumpas, Gert Luurtsema
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Nuclear Medicine
Subjects:
long axial field of view PET
pharmacokinetics
venous sampling
quantitative analysis
IDIF
kinetic analyses
Online Access:https://www.frontiersin.org/articles/10.3389/fnume.2025.1597902/full
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https://www.frontiersin.org/articles/10.3389/fnume.2025.1597902/full

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