Temporal dynamics and metagenomics of phosphorothioate epigenomes in the human gut microbiome

Temporal dynamics and metagenomics of phosphorothioate epigenomes in the human gut microbiome

Abstract Background Epigenetic regulation of gene expression and host defense is well established in microbial communities, with dozens of DNA modifications comprising the epigenomes of prokaryotes and bacteriophage. Phosphorothioation (PT) of DNA, in which a chemically reactive sulfur atom replaces...

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Bibliographic Details
Main Authors: Shane R. Byrne, Michael S. DeMott, Yifeng Yuan, Farzan Ghanegolmohammadi, Stefanie Kaiser, James G. Fox, Eric J. Alm, Peter C. Dedon
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Microbiome
Subjects:
Human gut microbiome
Mouse gut microbiome
Phosphorothioate
Epigenetics
Mass spectrometry
PT-seq
Online Access:https://doi.org/10.1186/s40168-025-02071-4
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https://doi.org/10.1186/s40168-025-02071-4

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