Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help.

Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help.

<h4>Background</h4>Using in vivo mouse models, the mechanisms of CD4+ T cell help have been intensively investigated. However, a mechanistic analysis of human CD4+ T cell help is largely lacking. Our goal was to elucidate the mechanisms of human CD4+ T cell help of CD8+ T cell proliferat...

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Main Authors: Marcus O Butler, Osamu Imataki, Yoshihiro Yamashita, Makito Tanaka, Sascha Ansén, Alla Berezovskaya, Genita Metzler, Matthew I Milstein, Mary M Mooney, Andrew P Murray, Hiroyuki Mano, Lee M Nadler, Naoto Hirano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030229&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030229&type=printable

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