Activation of the Nrf2 Pathway by Sulforaphane Improves Hypoglycaemia-Induced Cognitive Impairment in a Rodent Model of Type 1 Diabetes

Activation of the Nrf2 Pathway by Sulforaphane Improves Hypoglycaemia-Induced Cognitive Impairment in a Rodent Model of Type 1 Diabetes

In diabetes, chronic hyperglycaemia leads to cognitive impairment, neurodegeneration and dementia. In a rodent model of streptozotocin (STZ)-induced type 1 diabetes (STZ-T1D), we previously demonstrated that recurrent hypoglycaemia (RH) further exacerbates this process through a mechanism involving...

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Bibliographic Details
Main Authors: Heather J. Merchant, Calum Forteath, Jennifer R. Gallagher, Albena T. Dinkova-Kostova, Michael L. J. Ashford, Rory J. McCrimmon, Alison D. McNeilly
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Antioxidants
Subjects:
diabetes
oxidative stress
Nrf2
cognition
hypoglycaemia
Online Access:https://www.mdpi.com/2076-3921/14/3/308
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