Increases in 4‐Acetaminobutyric Acid Generated by Phosphomevalonate Kinase Suppress CD8+ T Cell Activation and Allow Tumor Immune Escape

Increases in 4‐Acetaminobutyric Acid Generated by Phosphomevalonate Kinase Suppress CD8+ T Cell Activation and Allow Tumor Immune Escape

Abstract Certain metabolites in the tumor microenvironment (TME) can alter innate immunity. Here, it is shown how phosphomevalonate kinase (PMVK) allows hepatocellular carcinoma (HCC) cells to overcome the anti‐tumor immunity mediated by CD8+ T cells. In HCCs, depletion of PMVK is required to facili...

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Bibliographic Details
Main Authors: Xinyi Zhou, Zhiqiang Chen, Yijiang Yu, Mengjiao Li, Yu Cao, Edward V. Prochownik, Youjun Li
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
4‐Acetaminobutyric acids
GABAA receptors
immune escapes
PMVK
tumor metabolisms
Online Access:https://doi.org/10.1002/advs.202403629
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https://doi.org/10.1002/advs.202403629

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