Inflammation-targeted nanomedicine prevents tumor metastasis following photodynamic therapy by reversing epithelial-mesenchymal transition and ROS-mediated immunosuppression

Inflammation-targeted nanomedicine prevents tumor metastasis following photodynamic therapy by reversing epithelial-mesenchymal transition and ROS-mediated immunosuppression

Abstract Background Prolonging the duration of photodynamic therapy (PDT) enhances the level of reactive oxygen species (ROS), thereby facilitating tumor ablation. However, our findings indicated that excessive ROS not only induces epithelial-mesenchymal transition (EMT) but also creates an immunosu...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhengwei Song, Quanwei Sun, Wenshuo Yang, Yunlong Li, Chaoyu Hu, Chen Chen, Kang Liu, Wei Shen, Ye Yang, Dengke Yin
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Nanobiotechnology
Subjects:
Reactive oxygen species
Platelet
Neutrophil membrane
Tumor metastasis
Epithelial-mesenchymal transition
Photodynamic therapy
Online Access:https://doi.org/10.1186/s12951-025-03332-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12951-025-03332-y

Similar Items