Pharmacological screening of a new valproic acid derivative using the pharmacoencephalography method in rats

Pharmacological screening of a new valproic acid derivative using the pharmacoencephalography method in rats

Introduction. The naïve Bayes classifier combined with principal component analysis allows to distinguish the effects of antipsychotic agents effectively as well as evaluate their dose-dependency based on their impact on electroencephalogram parameters in rats. Further development of this method req...

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Main Authors: Yu. I. Sysoev, D. D. Shits, M. M. Puchik, T. A. Gutiy, E. V. Fedorova, V. A. Prikhodko, I. A. Titovich, A. S. Melekhova, A. Ya. Bespalov, I. S. Knyazeva, E. B. Shustov, S. V. Okovityi
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2024-06-01
Series:Разработка и регистрация лекарственных средств
Subjects:
valproic acid aminoester
pharmacoencephalography
electrocortigography
principal component analysis
naïve bayes classifier
rats
Online Access:https://www.pharmjournal.ru/jour/article/view/1811
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https://www.pharmjournal.ru/jour/article/view/1811

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