Altered co-expression patterns of synovial fluid proteins related to the immune system and extracellular matrix organization in late stage OA, compared to non-OA controls

Altered co-expression patterns of synovial fluid proteins related to the immune system and extracellular matrix organization in late stage OA, compared to non-OA controls

ObjectiveSynovial fluid contains proteins that may have been released from surrounding tissues, our aim was to gain new insights into the proteomic profiles of human synovial fluid in knees with and without osteoarthritis (OA).MethodsWe used synovial fluid from 11 patients with end-stage medial comp...

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Bibliographic Details
Main Authors: Jenny Lönsjö, Martin Rydén, Aleksandra Turkiewicz, Velocity Hughes, Jon Tjörnstand, Patrik Önnerfjord, Martin Englund, Neserin Ali
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
osteoarthritis
synovial fluid
proteomics
Olink
protein-protein coexpression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1523103/full
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