Structure and dynamics of the interaction of Delta and Omicron BA.1 SARS-CoV-2 variants with REGN10987 Fab reveal mechanism of antibody action

Structure and dynamics of the interaction of Delta and Omicron BA.1 SARS-CoV-2 variants with REGN10987 Fab reveal mechanism of antibody action

Abstract Study of mechanisms by which antibodies recognize different viral strains is necessary for the development of new drugs and vaccines to treat COVID-19 and other infections. Here, we report 2.5 Å cryo-EM structure of the SARS-CoV-2 Delta trimeric S-protein in complex with Fab of the recombin...

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Main Authors: Ekaterina N. Lyukmanova, Evgeny B. Pichkur, Dmitry E. Nolde, Milita V. Kocharovskaya, Valentin A. Manuvera, Dmitriy A. Shirokov, Daria D. Kharlampieva, Ekaterina N. Grafskaia, Julia I. Svetlova, Vassili N. Lazarev, Anna M. Varizhuk, Mikhail P. Kirpichnikov, Zakhar O. Shenkarev
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07422-9
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https://doi.org/10.1038/s42003-024-07422-9

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