MOLECULAR PATHOGENESIS OF SECONDARY ACUTE PROMYELOCYTIC LEUKEMIA

MOLECULAR PATHOGENESIS OF SECONDARY ACUTE PROMYELOCYTIC LEUKEMIA

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Balanced chromosomal translocations that generate chimeric oncoproteins are considered to be initiating lesions in the pathogenesis of acute myeloid leukemia. The most frequent is the t(15;17)(q22;q21), which fuses the PML and RARA genes, giving rise to acute promyelocytic leukemia (APL). An increas...

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Bibliographic Details
Main Authors: Melanie Joannides, Ashley N Mays, Anita R Mistry, Syed Khizer Hasan, Andreas Reiter, Joseph L Wiemels, Carolyn A Felix, Francesco Lo-Coco, Neil Osheroff, Ellen Solomon, David Grimwade
Format: Article
Language:English
Published: PAGEPress Publications 2011-10-01
Series:Mediterranean Journal of Hematology and Infectious Diseases
Subjects:
Leukemia, therapy related leukemia, Acute promyelocytic leukemia
Online Access:http://www.mjhid.org/index.php/mjhid/article/view/301
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http://www.mjhid.org/index.php/mjhid/article/view/301

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