Enhancement of gut barrier integrity by a Bacillus subtilis secreted metabolite through the GADD45A‐Wnt/β‐catenin pathway

Enhancement of gut barrier integrity by a Bacillus subtilis secreted metabolite through the GADD45A‐Wnt/β‐catenin pathway

Abstract Inflammatory bowel disease (IBD) represents a significant challenge to global health, characterized by intestinal inflammation, impaired barrier function, and dysbiosis, with limited therapeutic options. In this study, we isolated a novel strain of Bacillus subtilis (B. subtilis) and observ...

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Bibliographic Details
Main Authors: Shiqi Liu, Peiran Cai, Wenjing You, Mingshun Yang, Yuang Tu, Yanbing Zhou, Teresa G. Valencak, Yingping Xiao, Yizhen Wang, Tizhong Shan
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:iMeta
Subjects:
2‐hydroxy‐4‐methylpentanoic acid
GADD45A
intestinal barrier
metabolites
probiotics
Wnt/β‐catenin signaling
Online Access:https://doi.org/10.1002/imt2.70005
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https://doi.org/10.1002/imt2.70005

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