Trispecific SEED antibodies engineered for neutrophil-mediated cell killing

Trispecific SEED antibodies engineered for neutrophil-mediated cell killing

Immunoglobulin (Ig) A has attracted interest as a proposed therapeutic agent due to its ability to engage cell groups differently compared to an IgG scaffold and elicit tumor eradication. Further, its multimeric forms enable increased flexibility in the design of available paratopes. The latter is p...

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Bibliographic Details
Main Authors: Veronica Natale, Gergely Heves, Katharina Stadlbauer, Florian Rüker, Vanessa Siegmund, Lukas Pekar, Stefan Zielonka, Lars Toleikis, Stefan Becker, Gordana Wozniak-Knopp
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
ADCC
bispecific antibody
EGFR
Fc alpha RI
immunoglobulin a
neutrophils
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2532851
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https://www.tandfonline.com/doi/10.1080/19420862.2025.2532851

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