Effect of multiple-dose administration of carprofen on hematological and biochemical parameters in sheep
<b>Aim:</b> The aim of this study was to determine the effects of carprofen on hematological and biochemical parameters following repeated intravenous administration of different doses.<p> <b>Materials and Methods:</b> Twenty healthy Akkaraman sheep were enrolled. The a...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2020-10-01
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1293 |
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| author | Duygu Durna Çorum Ramazan Yıldız |
| author_facet | Duygu Durna Çorum Ramazan Yıldız |
| author_sort | Duygu Durna Çorum |
| collection | DOAJ |
| description | <b>Aim:</b> The aim of this study was to determine the effects of carprofen
on hematological and biochemical parameters following repeated
intravenous administration of different doses.<p>
<b>Materials and Methods:</b> Twenty healthy Akkaraman sheep were
enrolled. The animals were randomly divided into two equal groups.
Carprofen was administered intravenously to the sheep in the first
group at a dose of 4 mg/kg, and to the sheep in the second group at a
dose of 16 mg/kg once a day for 5 days. To evaluation of hemogram
and biochemical panel blood samples were taken before carprofen
administration (0 hours) and 12, 24, 48, and 120 hours after administration.<p>
<b>Results: </b>There was no difference between hematological and biochemical
parameters of different dose administration groups. The
highest potassium, blood urea nitrogen, aspartate amino transferase
and total protein levels were determined at the 12th hour after administration
of 4 mg/kg carprofen. The highest troponin-I level was
seen at the 12th hour after administration of 16 mg/kg carprofen.
However, the decrease in the levels of red blood cells, hemoglobin
and hematocrit at a dose of 16 mg/kg was more marked, this change
was within the normal reference values.<p>
<b>Conclusion: </b>It has been observed that carprofen can be used safely
at 4 mg/kg and 16 mg/kg doses for 5 days in the sheep. However,
safety needs to confirm by histopathological and molecular studies. |
| format | Article |
| id | doaj-art-ec934026bff64d2cb49d7af904ead1f8 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-ec934026bff64d2cb49d7af904ead1f82025-02-03T11:25:38ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532020-10-013631661711293Effect of multiple-dose administration of carprofen on hematological and biochemical parameters in sheepDuygu Durna Çorum0Ramazan Yıldız1Kastamonu Üniversitesi Veteriner Fakültesi Farmakoloji ve Toksikoloji Anabilim Dalı, Kastamonu, TürkiyeMehmet Akif Ersoy Üniversitesi Veteriner Fakültesi İç Hastalıkları Anabilim Dalı, Burdur, Türkiye<b>Aim:</b> The aim of this study was to determine the effects of carprofen on hematological and biochemical parameters following repeated intravenous administration of different doses.<p> <b>Materials and Methods:</b> Twenty healthy Akkaraman sheep were enrolled. The animals were randomly divided into two equal groups. Carprofen was administered intravenously to the sheep in the first group at a dose of 4 mg/kg, and to the sheep in the second group at a dose of 16 mg/kg once a day for 5 days. To evaluation of hemogram and biochemical panel blood samples were taken before carprofen administration (0 hours) and 12, 24, 48, and 120 hours after administration.<p> <b>Results: </b>There was no difference between hematological and biochemical parameters of different dose administration groups. The highest potassium, blood urea nitrogen, aspartate amino transferase and total protein levels were determined at the 12th hour after administration of 4 mg/kg carprofen. The highest troponin-I level was seen at the 12th hour after administration of 16 mg/kg carprofen. However, the decrease in the levels of red blood cells, hemoglobin and hematocrit at a dose of 16 mg/kg was more marked, this change was within the normal reference values.<p> <b>Conclusion: </b>It has been observed that carprofen can be used safely at 4 mg/kg and 16 mg/kg doses for 5 days in the sheep. However, safety needs to confirm by histopathological and molecular studies.http://eurasianjvetsci.org/pdf.php3?id=1293biochemicalcarprofenhematologicalsheepside effect |
| spellingShingle | Duygu Durna Çorum Ramazan Yıldız Effect of multiple-dose administration of carprofen on hematological and biochemical parameters in sheep Eurasian Journal of Veterinary Sciences biochemical carprofen hematological sheep side effect |
| title | Effect of multiple-dose administration of carprofen on hematological and biochemical parameters in sheep |
| title_full | Effect of multiple-dose administration of carprofen on hematological and biochemical parameters in sheep |
| title_fullStr | Effect of multiple-dose administration of carprofen on hematological and biochemical parameters in sheep |
| title_full_unstemmed | Effect of multiple-dose administration of carprofen on hematological and biochemical parameters in sheep |
| title_short | Effect of multiple-dose administration of carprofen on hematological and biochemical parameters in sheep |
| title_sort | effect of multiple dose administration of carprofen on hematological and biochemical parameters in sheep |
| topic | biochemical carprofen hematological sheep side effect |
| url | http://eurasianjvetsci.org/pdf.php3?id=1293 |
| work_keys_str_mv | AT duygudurnacorum effectofmultipledoseadministrationofcarprofenonhematologicalandbiochemicalparametersinsheep AT ramazanyıldız effectofmultipledoseadministrationofcarprofenonhematologicalandbiochemicalparametersinsheep |