The endoplasmic reticulum stress status of CD4+ T lymphocytes and its association with mTOR-mediated autophagic-lysosomal disorder in elderly sepsis patients

The endoplasmic reticulum stress status of CD4+ T lymphocytes and its association with mTOR-mediated autophagic-lysosomal disorder in elderly sepsis patients

Aimsto clarify the endoplasmic reticulum stress (ERS) status of CD4+ T lymphocytes in sepsis patients, particularly elderly individuals aged over 65 years, and to elucidate its association with mTOR-mediated autophagic-lysosomal disorder.Methods62 sepsis patients were enrolled from January 1 to July...

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Bibliographic Details
Main Authors: Wei Cheng, Jiahui Zhang, Dongkai Li, Yawen Xie, Xianli Lei, Hao Wang, Na Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
endoplasmic reticulum stress
sepsis
elderly
mTOR
autophagiclysosomal disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1648075/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1648075/full

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